Histological and histochemical changes in the columnar lined (Barrett's) oesophagus.
نویسندگان
چکیده
منابع مشابه
Histological and histochemical changes in the columnar lined (Barrett's) oesophagus.
Multiple endoscopic specimens were obtained from 58 patients with a columnar lined gesophagus to study the histological and histochemical features of this metaplastic epithelium. Five patients (8.6%) had presented with a primary oesophageal adenocarcinoma. Three different epithelial types, junctional, atrophic fundic and intestinal were identified. Twenty two (38%) patients had just one type of...
متن کاملThe role of smoking and alcohol in metaplasia and cancer risk in Barrett's columnar lined oesophagus.
Smoking and alcohol consumption predispose to oesophageal mucosal damage and exacerbates gastro-oesophageal reflux. The alcohol and smoking habits of patients with severe oesophagitis (n = 24), Barrett's columnar lined oesophagus (CLO) (n = 58), and adenocarcinoma arising in CLO (n = 23) were studied. There was no significant difference between the age (median 67, 64, and 65 years respectively)...
متن کاملPrevalent low-grade dysplasia: the strongest predictor of malignant progression in Barrett's columnar-lined oesophagus.
Dear Professor Emad El-Omar, We read with interest the work by Duits et al who find that validated low-grade dysplasia (LGD) is highly predictive of malignant progression in Barrett’s oesophagus (BO). Yachimski stresses the need for this important finding to be validated in other centres. Our experience of prevalent LGD as a predictor of malignant progression in BO in the West of Scotland stron...
متن کاملAssessment of proliferation of squamous, Barrett's and gastric mucosa in patients with columnar lined Barrett's oesophagus
There is no satisfactory biomarker yet available for predicting the likelihood of premalignant changes or carcinoma developing in Barrett's or columnar lined oesophagus. In this study we have evaluated the proliferation of squamous epithelium, columnar epithelium from columnar lined oesophagus and gastric columnar epithelium from 23 Barrett's patients using positive immunoreactivity with the mo...
متن کاملThe columnar lined oesophagus: a riddle wrapped in a mystery inside an enigma.
Just a few years ago, the definition and pathogenesis of Barrett’s oesophagus seemed straightforward. Barrett’s oesophagus was the condition in which metaplastic columnar epithelium replaced oesophageal squamous mucosa that had been damaged by exposure to refluxed gastric juice. The condition was sought primarily in patients with gastro-oesophageal reflux disease (GORD), and was identified when...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gut
سال: 1986
ISSN: 0017-5749
DOI: 10.1136/gut.27.9.1062